Hoodia Gordonii works by mimicking the effect that glucose has on the nerve cells in the brain. These cells transmit the feeling of fullness to the brain, diminishing appetite. An appetite suppressant is an effective tool in any weight loss program, especially when combined with other dietary changes. You eat less, consume fewer calories, lose weight. Hoodia Gordoni can also be useful for helping to sustain you during days of strenuous physical exertion, such as marathon running.